Question
Ischemic colitis is associated with the use of
| A. |
Palonosetron
|
| B. |
Alosetron
|
| C. |
Dolasetron
|
| D. |
Ondansetron
|
Show Answer
|
Correct Answer � B
Explanation
|
|
Answer B) Alosetron
Alosetron, sold under the brand name Lotronex among others, is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.
Adverse effect
- Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects.
- The cumulative incidence of ischaemic colitis was 2 in 1000, while serious complications arising from constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 in 1000
