Question
A patient presents with generalized edema and anasarca suggestive of nephrotic syndrome. Minimal Change Disease (MCD) is suspected. Which of the following is the most specific diagnostic feature of Minimal Change Disease?
| A. |
Excellent response to corticosteroid therapy
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| B. |
Effacement (fusion) of podocyte foot processes on electron microscopy
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| C. |
Higher prevalence in adults than in children
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| D. |
Presence of non-selective proteinuria
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Show Answer
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Correct Answer » B
Explanation
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Diffuse effacement of podocyte foot processes seen on electron microscopy is the hallmark and most specific diagnostic feature of MCD. Light microscopy appears normal, and immunofluorescence is negative. Therefore, electron microscopy is required for definitive diagnosis.
Explanation of Other Options:
A. Excellent response to corticosteroid therapy
This is a characteristic clinical feature of MCD, particularly in children, but it is not diagnostic. Other diseases may also respond to steroids.
C. Higher prevalence in adults compared to children
Incorrect. MCD is most common in children and less common in adults.
D. Presence of non-selective proteinuria
Incorrect. MCD typically shows selective proteinuria (mainly albumin). Non-selective proteinuria is seen in more severe glomerular diseases like FSGS.
