Correct answer is B. Urine urobilinogen is increased in obstructive jaundice
urobilinogen is not increased in obstructive jaundice; it is absent. In obstructive jaundice, there is a blockage of the bile ducts, preventing bilirubin from reaching the intestine. Since urobilinogen is formed by the action of intestinal bacteria on bilirubin, its absence in the urine indicates a blockage in the bile ducts.
Now, let’s analyze the other options:
A. In hemolytic jaundice, urine bilirubin is indeed absent because the excess bilirubin is unconjugated and therefore not water-soluble.
C. Criggler-Najjar syndrome is characterized by a deficiency in the enzyme UDP-glucuronosyltransferase (UGT1A1), leading to unconjugated hyperbilirubinemia.
D. In hepatocellular jaundice, urine urobilinogen may be normal or decreased due to liver damage, which impairs the conversion of bilirubin to urobilinogen.
