Question
Vaccine-associated poliomyelitis is chiefly seen with which of the following strains of oral poliovirus?
| A. |
OPV 1 only
|
| B. |
OPV 2
|
| C. |
OPV 3 only
|
| D. |
Both OPV 1 and OPV 3
|
Show Answer
|
Correct Answer » C
Explanation
|
|
- Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of the live attenuated Oral Poliovirus Vaccine (OPV).
- It occurs due to reversion of the attenuated vaccine virus to a neurovirulent form.
- According to the provided study material, VAPP is chiefly associated with the mutated Type 3 (Sabin Type 3) strain.
Why Other Options are Incorrect
A. OPV Type 1 only
- Incorrect.
- Type 1 can rarely be associated with VAPP but is not the chief strain.
B. OPV Type 2
- Incorrect according to the provided source.
- Although type 2 has historically been implicated in circulating vaccine-derived poliovirus (cVDPV), the provided notes state that VAPP is chiefly due to the mutated Type 3 strain.
D. Both OPV Type 1 and OPV Type 3
- Incorrect.
- The major association is with Type 3 according to the provided source.
