Question
Consider the following vaccines:
- BCG Vaccine
- Hepatitis B Vaccine
- Inactivated Polio Vaccine (IPV)
- Oral Polio Vaccine (OPV)
What is the correct order of the above vaccines as per their sensitivity to heat (most sensitive to least sensitive) in the National Immunization Schedule (NIS)?
| A. |
4 → 3 → 2 → 1
|
| B. |
2 → 1 → 3 → 4
|
| C. |
2 → 4 → 3→ 1
|
| D. |
4 → 3 → 1 → 2
|
Show Answer
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Correct Answer » A
Explanation
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Clinical Reasoning for the Correct Answer:
– OPV (Oral Polio Vaccine) is the most heat-sensitive vaccine in NIS.
– IPV (Inactivated Polio Vaccine) is less sensitive than OPV but more sensitive than Hepatitis B and BCG.
– Hepatitis B vaccine is moderately heat-sensitive, less than OPV and IPV.
– BCG (Bacillus Calmette–Guérin) vaccine is least heat-sensitive among these and may even tolerate freezing.
Why Option A is Correct:
– Lists the vaccines in the exact heat sensitivity order: OPV (most) → IPV → Hepatitis B → BCG (least).
Why Option B is Incorrect:
– States Hepatitis B as most sensitive, but OPV is more heat-sensitive than Hepatitis B.
– BCG is not more sensitive than IPV or OPV.
Why Option C is Incorrect:
– Lists Hepatitis B as most sensitive (incorrect).
– Places BCG as least sensitive correctly, but the intermediate order (Hepatitis B → OPV → IPV) is wrong.
Why Option D is Incorrect:
– Correctly places OPV and IPV as most and second most sensitive, but BCG is NOT more heat-sensitive than Hepatitis B.
– BCG must come last, not before Hepatitis B.
