Question
A pregnant woman in 2nd trimester of pregnancy from North Eastern State has been diagnosed with uncomplicated P. falciparum. She should be treated with:
| A. |
Artemether and Lumefantrine
|
| B. |
Artesunate and Sulphadoxine
|
| C. |
Artesunate, Sulphadoxine and Pyrimethamine
|
| D. |
Chlorine and Primaquine
|
Show Answer
|
Correct Answer » A
Explanation
|
|
- North-Eastern states of India have significant resistance to Sulfadoxine-Pyrimethamine (SP).
- Therefore, for uncomplicated P. falciparum malaria, the recommended Artemisinin-based Combination Therapy (ACT) is:
- Artemether + Lumefantrine (AL)
Why Other Options Are Incorrect
B. Artesunate + Sulfadoxine
- Incomplete regimen.
- Sulfadoxine should be combined with Pyrimethamine.
C. Artesunate + Sulfadoxine + Pyrimethamine
- Recommended in many other parts of India.
- Not preferred in North-Eastern states because of SP resistance.
D. Chloroquine + Primaquine
- Chloroquine is ineffective against most P. falciparum infections due to resistance.
- Primaquine is contraindicated during pregnancy.
