Metabolism of Pyrimidine
METABOLISM OF PYRIMIDINE
Biosynthesis of Pyrimidine-
- Its main site is liver.
- It takes place in cytoplasm and mitochondria organelle.
- Pyrimidine nucleotides are-
- Cytidine monophosphate (CMP)
- Uridine monophosphate (UMP)
- Thymidine monophosphate (TMP)
- Precursors for de novo synthesis of pyrimidine are.
- Glutamins provides N3
- Aspartic acid furnishes C4, C5, C6, and N1
- CO2 provides C2
- De Novo Pyrimidine Synthesis-
- Pyrimidine synthesis starts with the formation of carbamoyl phosphate from glutamine, ATP and CO2 and catalyzed by carbamoyl phosphate synthase- II (CPS II).
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Enzymes of Pyrimidine synthesis-
- Carbamoyl phosphate synthase- II
- Aspartate transcarbamoylase
- DHOA dehydrogenase is the only mitochondrial enzyme.
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Salvage of pyrimidines-
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Pyrimidine nucleosides can be salvaged by nucleoside kinase
- Disorder of Pyrimidine Metabolism-
- Orotic aciduria
Exam Important
1. Precursors for de novo synthesis of pyrimidine are.
- Glutamins provides N3
- Aspartic acid furnishes C4, C5, C6, and N1
- CO2 provides C2
2. Aspartate transcarbamoylase catalyzes a coomitted step in pyrimidine synthesis.
3. Pyrimidines are degraded to amino acids, namely β- alanine and β- aminoisobutyrate which are then metabolized.
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