Mucopolysaccharides (Glycosaminoglycan)

Mucopolysaccharides (Glycosaminoglycan)

Q. 1 Mucin CLOT test is done to detect:
 A Mucin in stool
 B Protein in CSF
 C Hyaluronate in synovial fluid
 D Protein in pleural fluid
Q. 1 Mucin CLOT test is done to detect:
 A Mucin in stool
 B Protein in CSF
 C Hyaluronate in synovial fluid
 D Protein in pleural fluid
Ans. C

Explanation:

Hyaluronate in synovial fluid


Q. 2

All are examples of glycosaminoglycans, EXCEPT:

 A

Hyaluronic acid

 B

Chondroitin sulfate

 C

Heparin

 D

None of the above

Ans. D

Explanation:

Glycosaminoglycans (mucopolysaccharides) are complex carbohydrates containing amino sugars and uronic acids. They may be attached to a protein molecule to form a proteoglycan.
 
Proteoglycans provide the ground or packing substance of connective tissue.
They hold large quantities of water and occupy space, thus cushioning or lubricating other structures, because of the large number of —OH groups and negative charges on the molecule which, by repulsion, keep the carbohydrate chains apart. Examples are hyaluronic acid, chondroitin sulfate, and heparin
Ref: Harper 28th edition, chapter 14.

 


Q. 3

Hyaluronic acid – mucopolysaccharide is present in

 A

Cornea

 B

Mast cell

 C

Vitreous humor

 D

Dermis

Ans. C

Explanation:

C i.e. Vitreous humor


Q. 4

Heparin is –

 A

Polysaccharide

 B

Lipoprotein

 C

Monosaccharide

 D

Polyenoic acid

Ans. A

Explanation:

Ans. is `a’ i.e., Polysaccharide

o Heparin is mucopolysaccharide.


Q. 5

Uronic acid pathway does not have a role in the formation of which Proteoglycan:

 A

Keratan sulfate

 B

Chondroitin sulfate

 C

Hyaluronic acid

 D

Heparan sulfate

Ans. A

Explanation:

Glycosaminoglycans are heteropolysaccharide (heteropolysaccharides are polysaccharides which contain two or more different monosaccharide unit or their derivates).

Keratan Sulfate- It is the only GAG that does not contain any uronic acid. The repeating units are galactose and N-acetyl glucosamine in the beta-linkage. It is found in cornea and tendons.


Q. 6

Mucopolysaccharide having anticoagulant action is‑

 A

Heparin

 B

Phenindione

 C

Rivoroxaban

 D

Dabigatran

Ans. A

Explanation:

Ans. is ‘a’ i.e., Heparin

Heparin

  • It is a parenteral indirect thrombin inhibitor.
  • It is a on uniform mixture of straight chain polysaccharides with molecular weight 10, 000 – 20, 000.
  • It contains polymers of two sulfated disaccharide units D glucosamine L iduronic acid and D glucosamine D glucuronic acid.
  • Heparin is the strongest organic acid present in the body.


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