NEURONAL TRANSPORT

NEURONAL TRANSPORT


NEURONAL/AXOPLASMIC TRANSPORT

Types:

  • Slow
  • Fast

FAST AXOPLASMIC TRANSPORT:

Subtypes:

  • Antegrade
  • Retrograde

FAST ANTEGRADE TRANSPORT:

  • Velocity of conduction – 400 mm/day
  • Occurs along microtubules & driven by kinesin.

Main function:

  • Transports membrane-bounded organelles like ER, mitochondria, Golgi derived vesicles, microvesicles containing neurotransmitter/lipid/proteins, actin, myosin & clathrin.

FAST RETROGRADE TRANSPORT:

  • Velocity of conduction 200 mm/day
  • This also occurs along microtubules & driven by dynein.

Main function:

  • Transports empty (used) microvesicles for recycling or degradation by lysosomes, nerve growth factors, toxins (tetanus toxin & neurotoxins) and viruses (herpes, polio & rabies).

SLOW AXOPLASMIC TRANSPORT:

  • Velocity of conduction 0.5-10mm/day.
  • Occurs due to complete shift of cytoskeleton.

Main function:

  • Carries protein subunits of neurofilament.
  • Transports tubulin of microtubules.
  • Movement of soluble enzyme for neurotransmitter synthesis.

Exam Important

NEURONAL/AXOPLASMIC TRANSPORT

Types:

FAST AXOPLASMIC TRANSPORT:

1. Fast antegrade transport:

  • Occurs along microtubules & driven by kinesin.

2. Fast retrograde transport:

  • This also occurs along microtubules & driven by dynein.

SLOW AXOPLASMIC TRANSPORT:

  • Carries protein subunits of neurofilament.
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