Polysaccharides
| A | Blood group matching | |
| B |
Causes thrombocytopenia |
|
| C |
↓ Microcirculation formation |
|
| D |
a and b |
Dextran is a good plasma expanders, but it has disadvantage of –
| A |
Blood group matching |
|
| B |
Causes thrombocytopenia |
|
| C |
↓ Microcirculation formation |
|
| D |
a and b |
Ans. is ‘a’ i.e., Blood group matching; ‘b’ i.e., Causes thrombocytopenia
o Dextran is a polysaccharide obtained form sugar beet. It is plasma expander and have all properties of an ideal plasma expander except :
a) May interfere with blood grouping and cross matching.
b) Some polysaccharide reacting antibodies if present in pts may cross-react with dextran and trigger an anaphylactoid reaction. (Though the dextran is not antigenic).
c) They coat the platelets and coagulation factors and may interfere with coagulation and platelet function, thus prolong bleeding times. Not used when hypofibrinogenemia, thrombocytopenia or bleeding pts.
Dextran prevent roleaux formation of RBC’s and have anti-sludging effects, thereby increases microcirculation.
Which of the following is a homopolysaccharide‑
| A | Heparin | |
| B |
Chitin |
|
| C |
Hyaluronic acid |
|
| D |
Chondroitin sulfate |
Ans. is ‘b’ i.e., Chitin
Polysaccharides are classified into ‑
a) Homopolysaccharides (Homoglycans) :- This type of polysaccharide is made up of several units of same monosaccharide unit only. Examples are starch (multiple units of glucose), glycogen (multiple units of glucose), cellulose (multiple units of glucose), Inulin (multiple unit of fructose), Dextrin, Dextran (multiple units of glucose), and chitin.
b) Heteropolysaccharides (Heteroglycans) :- This type of polysaccharide contains two or more different types of monosacharide units. Examples are heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, hyaluronic acid, keratan sulfate and blood group polysaccharides.
