Prenicious anemia
| A | Pre pyloric region | |
| B |
Pylorus |
|
| C |
Body |
|
| D |
Fundus |
When carcinoma of stomach develops secondarily to pernicious anemia, it is usually situated in the
| A |
Pre pyloric region |
|
| B |
Pylorus |
|
| C |
Body |
|
| D |
Fundus |
Ans. is ‘d’ i.e. Fundus
- Gastric carcinomas arising in pernicious anemia differ from usual gastric cancer in following ways
i) polypoid
ii) fundic or cardiac rather than antral in origin
iii) multicentric of low average grade of malignancy.
| A | Prepyloric region | |
| B |
Pylorus |
|
| C |
Body |
|
| D |
All |
Answer is C (Fundus> Body)
Atrophic glands with extensive intestinal metaplasia are most charachteristically confined to the ‘Midas in patients with pernicious anaemia.
Pernicious anemia is associated with autoimmune atrophic gastritis affecting the fundic glands.Intestinal metaplasia (premalignant jar gastric carcinoma), is charachterstically seen in this area of atrophic gastritis .Atrophic glands with extensive intestinal metaplasia are most charachteristically confined to the fundus in patients with pernicious anaemia.Gastric cancer in case of pernicious anemia is most often located in the fundus or body of the stomach rather in the Antrum.
| A | Gastric pathology | |
| B |
Renal pathology |
|
| C |
Esophageal pathology |
|
| D |
Oral pathology |
Ans. is ‘a’ i.e., Gastric Pathology
Anemias of Vitamin B12 Deficiency: Pernicious Anemia
- Pernicious anemia is a specific form of megaloblastic anemia caused by an autoimmune gastritis that impairs the production of intrinsic factor, which is required fir vitamin B12 uptake from the gut.
- Histologically, there is a chronic atrophic gastriti smarked by loss of parietal cells, prominent infiltrate of lymphocytes and plasma cells, and megaloblastic changes in mucosal cells.
