PROPOFOL

PROPOFOL

Q. 1 Propofol is used as the drug of choice for inducing anesthesia in which of the following situation?

 A Neurosurgery

 B

Day care surgery

 C

Cardiac surgery

 D

In neonates

Q. 1

Propofol is used as the drug of choice for inducing anesthesia in which of the following situation?

 A

Neurosurgery

 B

Day care surgery

 C

Cardiac surgery

 D

In neonates

Ans. B

Explanation:

It is the induction agent of choice in day care surgery.

The half life is 100 minutes, but the clinical effects of a single dose of propofol lasts only for 10 minutes due to its rapid redistribution.

It has minimal residual impairment, anti emetic and anti pruritic property, making it a suitable drug for day care surgery.


Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 343


Q. 2

Which of the following statements about propofol is not true?

 A

It is contraindicated in porphyria

 B

It does not trigger malignant hyperthermia

 C

Commercial preparations contains egg

 D

It is a suitable agent for day care surgery

Ans. A

Explanation:

Propofol can be used safely in porphyria.

Propofol is the recommended agent of choice for induction in susceptible individuals for malignant hyperthermia.

Smooth induction, rapid onset of action, easy titration to effect,

short clinical duration of action and demonstrable antiemetic effect make propofol an induction agent of choice for day care anaesthesia.

Ref: Lee’s Synopsis of Anesthesia, 13th Edition, Pages 158-60; Short Textbook of Anaesthesia By Ajay Yadav, 2nd Edition, Page 74 and 3rd Edition, Page 37; Handbook of Clinical Anesthesia By Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, M. Christine Stock , 6th Edition, Pages 257-259; Clinical Anesthesia By Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, Michael Cahalan, 6th Edition, Page 461


Q. 3

Propofol is a drug that is used and misused frequently. 
 
Assertion: Propofol is indicated mainly in daycare surgeries.
 
Reason: It is associated with less residual impairment and low incidence of postoperative nausea and vomiting.
 A

Both Assertion and Reason are true, and Reason is the correct explanation for Assertion

 B

Both Assertion and Reason are true, and Reason is not the correct explanation for Assertion

 C

Assertion is true, but Reason is false

 D

Assertion is false, but Reason is true

Ans. A

Explanation:

Propofol is an intravenous anaesthetic used as a 1% emulsion for iv induction and short duration anaesthesia.

It lacks airway irritancy and is particularly suitable for day care surgeries because of less residual impairment

and a low incidence of postoperative nausea and vomiting.


Q. 4

All are true about propofol except

 A

Plesant sedation & recovery

 B

Safe in porphyria

 C

Antiemetic effect

 D

Cardiac stimulant

Ans. D

Explanation:

D i.e. Cardiac stimulant


Q. 5

Which of the following is the best indication for propofol as an intravenous induction agent?

 A

Neurosurgery

 B

Day care surgery

 C

Patients with coronary artery disease

 D

In neonatesq

Ans. B

Explanation:

B i.e. Day care surgery


Q. 6

Following statements are true for propofol except:

March 2012

 A

Painful intravenous administration

 B

Induction agent

 C

Contraindicated in porphyria

 D

Antiemetic effect

Ans. C

Explanation:

Ans: C i.e. Contraindicated in porphyria

Propofol

  • Side effects of propofol include pain on injection
  • Propofol can be used for both induction as well as maintenance
  • Propofol is safer in porphyria
  • Propofol possess significant antiemetic action

Q. 7

Propofol infusion syndrome all except‑

 A Occurs with infusion of propofol for 48 hours or longer

 B Occurs in critically ill patients

 C

Features are nausea and vomiting

 D

Features are cardiomyopathy, hepatomegaly

Ans. C

Explanation:

Ans. is ‘c’ i.e., Features are nausea and vomiting

Propofol infusion syndrome

  • A lethal syndrome, associated with infusion of propofol for 48 hours or longer.
  • Occurs in children and critically ill.
  • Occurs as a result of failure of free fatty acid metabolism and failure of the mitochondrial respiratory chain.
  • Features are-cardiomyopathy with acute cardiac failure, metabolic acidosis, skeletal myopathy, hyperkalemia, hepatomegaly and lipemia.


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