Corynebacterium Diphtheria: Clinical manifestation, Complications, Diagnosis and Treatment

Corynebacterium Diphtheria: Clinical manifestation, Complications, Diagnosis and Treatment

Q. 1

Positive Schick test indicates

 A

Immune to diphtheria

 B

Immune and hypersensitive to diphtheria

 C

Susceptible and hypersensitive to diphtheria

 D

Susceptible to diphtheria

Q. 1

Positive Schick test indicates

 A

Immune to diphtheria

 B

Immune and hypersensitive to diphtheria

 C

Susceptible and hypersensitive to diphtheria

 D

Susceptible to diphtheria

Ans. D

Explanation:

Susceptible to diphtheria [Ref. Park 19th/e p 137]



Q. 2 Schick test in diphtheria is done to know:
 A Carriers
 B Subseceptibles
 C Diseased
 D Immunized
Q. 2 Schick test in diphtheria is done to know:
 A Carriers
 B Subseceptibles
 C Diseased
 D Immunized
Ans. B

Explanation:

Subseceptibles


Q. 3 “Eleks” test is for:
 A Influenza
 B Diptheria
 C Brucella
 D Cholera
Q. 3 “Eleks” test is for:
 A Influenza
 B Diptheria
 C Brucella
 D Cholera
Ans. B

Explanation:

Diptheria

Quiz In Between


Q. 4

Post exposure prophylaxis in health care professionals is indicated in infections with all except?

 A

HBV

 B

Rabies

 C

Diptheria

 D

Measles

Q. 4

Post exposure prophylaxis in health care professionals is indicated in infections with all except?

 A

HBV

 B

Rabies

 C

Diptheria

 D

Measles

Ans. C

Explanation:

Post exposure prophylaxis is used in HIV, HBV, Measles, Rabies, Tetanus, H.influenzae and Meningococcus.

Ref: Park, 20th Edition, Pages 139, 189, 240, 283.

Q. 5

Skin test based on neutralization reaction is/are –

 A

Casoni test

 B

Lepromin test

 C

Tuberculin test

 D

Schick test

Q. 5

Skin test based on neutralization reaction is/are –

 A

Casoni test

 B

Lepromin test

 C

Tuberculin test

 D

Schick test

Ans. D

Explanation:

Ans. is ‘d i.e., Schick test


Q. 6

True about diptheria is –

 A

 Loffer’s serum is highly selective medium for C. diptheria

 B

Elek’s Gel is a precipitation test

 C

Metachromatic granules is produced on stain only by one strain of C. diphtheria

 D

Gm-ve bacilli, non motile, non capsulated

Q. 6

True about diptheria is –

 A

 Loffer’s serum is highly selective medium for C. diptheria

 B

Elek’s Gel is a precipitation test

 C

Metachromatic granules is produced on stain only by one strain of C. diphtheria

 D

Gm-ve bacilli, non motile, non capsulated

Ans. B

Explanation:

Ans. is ‘b’ i.e., Elek’s Gel is a precipitation test 

.  Elek’s is a precipitation test. It is an in vitro test for toxigenicity of the diphtheria bacillus.

.   Selective medium for C. diphtheriae is tellurite blood agar (eg. Mc Leod’s and Hoyle’s media or cystine – tellurite agar – Tinsdale medium).

.  All strains of C. diphtheriae show metachromatic granules on staining.

.  C. diphtheriae is gram (+) ye, nonmotile and non-capsulated.

Based on colonial morphology on tellurite agar and other properties, Mc Leod classified diphtheria bacilli into three bio types – gravis, intermedius and mitis. Gravis causing most serious and mitis the mildest variety of diphtheria.

Quiz In Between


Q. 7

True about Diptheria –

 A

Caused by Gram negative bacilli

 B

Incubation period 2-5 days

 C

Chemoprophylaxis is done with rifampicin

 D

All

Q. 7

True about Diptheria –

 A

Caused by Gram negative bacilli

 B

Incubation period 2-5 days

 C

Chemoprophylaxis is done with rifampicin

 D

All

Ans. B

Explanation:

Ans. is ‘b’ i.e.,Incubation period 2-5 days

.  Diptheria is caused by Gram positive bacilli, Corynebacterium diphtheriae

.   Incubation period of most common form of diphtheria ( faucial/ tonsiliopharyngeal diphtheria) is 2-5 days.

. For chemoprophylaxis erythromycin or penicillin are used.

Previously immunized asymptomatic household contact should receive booster dose of diphtheria toxoid. Those not fully immunized but asymptomatic contacts should receive immunization for their age”.—0.P. Ghai 7th/221 “Lifelong immunity is usually, but not always, acquired after disease or inapparent infection”—health.vic.gov.au> IDAES home > blue book

. So, child recovered from illness is already is immune. No active immunization is required.


Q. 8

The most common ophthalmic effect of diptheria is –

 A

Ptosis

 B

Total ophthalmoplegia

 C

Isolated ocular palsies

 D

Ophthalmoplegia externa

Q. 8

The most common ophthalmic effect of diptheria is –

 A

Ptosis

 B

Total ophthalmoplegia

 C

Isolated ocular palsies

 D

Ophthalmoplegia externa

Ans. C

Explanation:

Ans. is ‘c’ i.e., Isolated ocular palsies 

Complications

o Obstruction of the respiratory tract by pseudomembrane

o Myocarditis

  • Polyneuropathy
  • Post diphtheritic paralysis q Occurs in the 3rd or 4th week

o Palatine and pupillary paralysis is characteristic

Spontaneous recovery is the rule.

  • Pneumonia

o Other less common complications are renal failure, encephalitis, cerebral infarction, pulmonary embolism and bacteremia or endocarditis.


Q. 9

Commonest age group for diptheria is –

 A

1-2 Years

 B

2-5 Years

 C

2-7 Years

 D

2-9 Years

Q. 9

Commonest age group for diptheria is –

 A

1-2 Years

 B

2-5 Years

 C

2-7 Years

 D

2-9 Years

Ans. B

Explanation:

Ans. is ‘b’ i.e., 2-5 years 

Diphtheria

o Diphtheria is an acute infectious disease caused by toxigenic strains of corynebacterium diphtheriae.

o Source of infection –> cases or carriers; carriers are common sources of infection, their ratio is estimated to be 95 carriers for 5 clinical cases.

o Infective period              –> 14 – 28 days from the onset of disease.

o Age group                                     —> 1 to 5 years

o Sex                                    –> Both sexes

o Incubation period            –> 2 – 6 days

Quiz In Between


Q. 10

Regarding schick’s test which of the following is false –

 A

Erythematous reaction in both arms indicates  Allergic type interpreted as Schick type

 B

Positive test means that person is immune to hypersensitivity diphtheria

 C

Diphtheria antitoxin is given intradermal

 D

All

Q. 10

Regarding schick’s test which of the following is false –

 A

Erythematous reaction in both arms indicates  Allergic type interpreted as Schick type

 B

Positive test means that person is immune to hypersensitivity diphtheria

 C

Diphtheria antitoxin is given intradermal

 D

All

Ans. B

Explanation:

Ans. is ‘b’ i.e., Positive test means that person is immune to diphtheria 


Q. 11

Which of the following organism can penetrate the normal cornea :

 A

Gonococcus

 B

Pseudomonus

 C

Diptheria

 D

a and c

Q. 11

Which of the following organism can penetrate the normal cornea :

 A

Gonococcus

 B

Pseudomonus

 C

Diptheria

 D

a and c

Ans. D

Explanation:

A i.e. Gonococcus; C i.e. Diptheria 

The only organisms known to be able to invade normal corneal epithelium are N. gonorrhoea & Cornybacterium diptheria Q

Quiz In Between



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