REGULATION OF THIRST
REGULATION OF THIRST
- Regulated by thirst/drinking center located in lateral hypothalamus.
- Types of thirst:
- Osmotic thirst
- Volumetric thirst.
- Inputs received:
- For osmotic thirst – Osmoreceptor located in anterior hypothalamus.
- For volumetric thirst – Subfornical organ & Organ Vasculosum of Lamina Terminalis (OVLT).
MECHANISM OF THIRST:
- Osmotic thirst & osmoreceptors are activated when plasma osmolarity increases.
- Osmoreceptors are sensitive to intracellular dehydration and are insensitive to solutes like glucose & urea.
- Volumetric thirst, SFO & OVLT are activated when there is decreased ECF (hypovolemia).
- Also activates renin-angiotensin system producing angiotensin II.
- ADH is responsible for thirst mechanism during dehydration.
Exam Important
REGULATION OF THIRST
- Angiotensin II causes stimulation of thirst during volumetric thirst.
- ADH is responsible for thirst mechanism during dehydration.
- Osmoreceptors are present in anterior hypothalamus.
- Osmoreceptors are sensitive to intracellular dehydration and are insensitive to solutes like glucose & urea.
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