Pharmacological treatment of schizophrenia includes antipsychotics/neuroleptics.

Both typical and atypical antipsychotics are used

Typical antipsychotics (1st gen):

  • Acts Via D2 Receptor Antagonism
  • Effective Against Positive Symptoms
  • Minimal Effect on Negative Symptoms
  • Causes More Extrapyramidal Side Effects

Atypical antipsychotics (1st gen):

  • Acts Via D2 & 5HT 2 Receptor Antagonism
  • Effective Against (+) and (-) Symptoms
  • Causes Less Extrapyramidal Side Effects
  • Causes Less other Side Effects

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