Selective serotonin reuptake inhibitors

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Selective serotonin reuptake inhibitors

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SSSIs are-Fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine, vilazodone

• Act by blocking reuptake of serotonin
• First Line of T/T for

1. Depression
2. OCD
3. PTSD
4. Panic disorder
5. GAD
6. Phobias

Side Effect – Nausea [M/C], anxiety, diarrhea, delayed ejaculation, ↓ Libido, sedation, sweating, Weight gain, delayed platelet aggregation.

• Serotonin Syndrome

1. Concurrent SSRI + MAO Inhibitor, L tryptophan or lithium
2. Diarrhea, restlessness, hyperreflexia, myoclonus, seizures and even death
3. T/T – Cyproheptadine & Supportive care

• Vortioxetine – SSRI + Agonism 5HT1a receptor, Partial antagonist 5HT3, 5HT1D and 5HT7 receptor