Selective serotonin reuptake inhibitors


Selective serotonin reuptake inhibitors


SSSIs are-Fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine, vilazodone

  • Act by blocking reuptake of serotonin
  • First Line of T/T for
  1. Depression
  2. OCD
  3. PTSD
  4. Panic disorder
  5. GAD
  6. Phobias

Side Effect – Nausea [M/C], anxiety, diarrhea, delayed ejaculation, ↓ Libido, sedation, sweating, Weight gain, delayed platelet aggregation.

  • Serotonin Syndrome
  1. Concurrent SSRI + MAO Inhibitor, L tryptophan or lithium
  2. Diarrhea, restlessness, hyperreflexia, myoclonus, seizures and even death
  3. T/T – Cyproheptadine & Supportive care
  • Vortioxetine – SSRI + Agonism 5HT1a receptor, Partial antagonist 5HT3, 5HT1D and 5HT7 receptor

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