Selective serotonin reuptake inhibitors
SSSIs are-Fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine, vilazodone
- Act by blocking reuptake of serotonin
- First Line of T/T for
- Depression
- OCD
- PTSD
- Panic disorder
- GAD
- Phobias
Side Effect – Nausea [M/C], anxiety, diarrhea, delayed ejaculation, ↓ Libido, sedation, sweating, Weight gain, delayed platelet aggregation.
- Serotonin Syndrome
- Concurrent SSRI + MAO Inhibitor, L tryptophan or lithium
- Diarrhea, restlessness, hyperreflexia, myoclonus, seizures and even death
- T/T – Cyproheptadine & Supportive care
- Vortioxetine – SSRI + Agonism 5HT1a receptor, Partial antagonist 5HT3, 5HT1D and 5HT7 receptor