side effects

Side effects of typical antipsychotics

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Side effects of typical antipsychotics The side effects of typical antipsychotics include: Movement disorders Endocrine effects Sedation Movement disorders: Movement Disorders also called Extrapyramidal Symptoms Caused by Blockage of Dopamine receptors in Nigrostriatal tract Acute dystonia: Earliest Side Effect. Sudden contraction of a grp. of muscles [torticollis, trismus, deviation of eye] Mgt – I/V Anticholinergics […]

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Selective serotonin reuptake inhibitors

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Selective serotonin reuptake inhibitors SSSIs are-Fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine, vilazodone Act by blocking reuptake of serotonin First Line of T/T for Depression OCD PTSD Panic disorder GAD Phobias Side Effect – Nausea [M/C], anxiety, diarrhea, delayed ejaculation, ↓ Libido, sedation, sweating, Weight gain, delayed platelet aggregation. Serotonin Syndrome Concurrent SSRI + MAO Inhibitor,

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Basic principles of pharmacotherapy for depression

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Basic principles of pharmacotherapy for depression Specific pharmacotherapy doubles the chances of recovery in 1 month Most anti-depressants take 3-4 weeks to exert significant therapeutic effects Should be taken for 6 months or equal to duration of previous episode [which ever greater] Prophylactic advised if >3 episodes in a year or have chronic major depressive

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Etiology of depression

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Etiology of depression Biological Factors- Neurotransmitter [ ↓ Levels of Serotonin & NE and dopamine in some cases] Hormonal Disturbances [ Elevated activity in Hypothalamic-pituitary axis, Hypothyroidism Neuroanatomical – ↓ activity in dorsolateral prefrontal cortex and ↑ in amygdala [Limbic system] Genetic Factors- CERB 1 on Chromosome 2 [cAMP response element binding protein] Serotonin transporter

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