Sporothrix schenckii

Sporothrix schenckii

Q. 1 “Asteroid bodies” and “Cigar shaped globi” may be produced by:

 A Malassezia

 B

Sporotrichosis

 C

Phialophora

 D

Aspergillus

Q. 1

“Asteroid bodies” and “Cigar shaped globi” may be produced by:

 A

Malassezia

 B

Sporotrichosis

 C

Phialophora

 D

Aspergillus

Ans. B

Explanation:

Ans. B- Sporotrichosis

  • Sporothrix  schenckii is a thermally dimorphic fungus that lives on vegetation.
  • It is associated with a variety of plants— grasses, trees, sphagnum moss, rose bushes, and other horticultural plants.
  • Following traumatic introduction into the skin, S schenckii causes sporotrichosis, a chronic granulomatous infection.
  • Specimens include biopsy material or exudate from granulomatous or ulcerative lesions.
  • The yeasts are 3–5 μm in diameter and spherical to elongated. 
  • Another structure termed an asteroid body is often seen in tissue, particularly in endemic areas such as Mexico, South Africa, and Japan
  • An asteroid body is a microscopic finding seen within the giant cells of granulomas in diseases such as sarcoidosis and foreign-body giant cell reactions.
  • In hematoxylin and eosin-stained tissue, the asteroid body consists of a central basophilic yeast cell surrounded by radiating extensions of eosinophilic material, which are depositions of antigen-antibody complexes and complement

Q. 2 A man developed a pustule after striking by a thorn in the garden. Laboratory examination of the tissue specimen shows cigar-shaped budding yeasts. Most probable causative agent is:

 A

Sporothrix

 B

Sporotrichosis

 C

Phialophora

 D

Aspergillus

Ans. A

Explanation:

Sporothrix schenckii, is a dimorphic fungus. The mold form lives on plants and the yeast form occurs in human tissue.
When spores of the mold are introduced into the skin, typically by a thorn, it causes a local pustule or ulcer with nodules along the draining lymphatics.
In the clinical laboratory, round or cigar-shaped budding yeasts are seen in tissue specimens. In culture at room temperature, hyphae occur bearing oval conidia in clusters at the tip of slender conidiophores (resembling a daisy).
The drug of choice for skin lesions is itraconazole.
Ref: Levinson W. (2012). Chapter 48. Cutaneous & Subcutaneous Mycoses. In W. Levinson (Ed), Review of Medical Microbiology & Immunology, 12e.

Q. 3

A gardener has multiple vesicles on hand and multiple eruptions along the lymphatics. Most common fungus responsible is ?

 A

Sporothrix schenckii

 B

Cladosporium

 C

Histoplasma

 D

Candida

Ans. A

Explanation:

Ans. is ‘a’ i.e., Sporothrix schenckii

  • Multiple vesicles on hand and multiple eruptions along the lymphatics in a gardner suggest the diagnosis of cutaneous sporotrichosis.

Q. 4

A woman who pricked her finger while pruning some rose bushes develops a local pustule that progressed to an ulcer. Several nodules then developed along the local lymphatic drainage. The most likely etiological agent would be?

 A Aspergillus fumigatus

 B

Candida albicans

 C

Histoplasma capsula turn

 D

Sporothrix schenckii

Ans. D

Explanation:

Ans. is ‘d’ i.e., Sporothrix schenckii

  • Multiple vesicles on hand and multiple eruptions along the lymphatics in a Gardner suggest the diagnosis of cutaneous sporotrichosis.

Q. 5 A patient, resident of Himachal Pradesh presented with a series of ulcers in a row, on his right leg. The biopsy from the affected area was taken and cultured on Sabouraud’s Dextrose agar. What would be the most likely causative organism?

 A

Sporothrix schenckii

 B

Cladosporium spp.

 C

Pseudoallescheria boydii

 D

Nocardia

Ans. A

Explanation:

Ans. is ‘a’ i.e., Sporothrix schenckii

.   Series of ulcers in a row suggests the diagnosis of sporotrichosis.


Q. 6 A former from the sub-Himalayan region presents with multiple leg ulcers. The most likely causative agent is –

 A

Trichophyton Rubrum

 B

Cladosporium species

 C

Sporothrix Schenckii

 D

Aspergillus

Ans. C

Explanation:

Ans. is ‘c’ i.e., Sporothrix Schenckii

  • Presence of multiple ulcers in the leg (along the lymphatic channels) in a farmer (out door worker) from the sub himalyan region suggests a diagnosis of Sporothrix Schenkii.

Q. 7 Asteroid bodies and cigar shaped globi may be produced by-

 A

Sporothrix

 B

Sporotrichosis

 C

Phialophora

 D

a and b

Ans. D

Explanation:

Ans. is ‘a’ i.e., Sporothrix; ‘b’ i.e., Sporotrichosis

. Some times ‘asteroid bodies’ are seen in the lesion of sporotrichosis, composed of a central fungus cell with eosinophilic material radiating from it.

 


Q. 8

Which of the following is a dimorphic

 A

Rhizopus

 B

Sporothrix schenckii

 C

Tinea versicolor

 D

Microsporum

Ans. B

Explanation:

Ans. is ‘b’ i.e., Sporothrix schenckii



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