 Clozapine First Atypical antipsychotic and is Drug of Choice in RESISTANT Schizophrenia Low D2 Affinity [Lack of Extrapyramidal S/E]and Strong D4 Affinity Antagonist of 5HT2A, D1, D3 and Alpha-adrenergic receptor Preferred Antipsychotic in patient who with EPM side effects including tardive dyskinesia S/E – Sedation, Syncope, hypotension, tachycardia, Nausea & Vomiting, Weight Gain [Highest], […]
Clozapine CLOZAPINE INDICATIONS: Suicidal Behaviour. Treatment-resistant schizophrenia In advanced dopamino-mimetic psychosis. Patients intolerant to typical neuroleptic drugs because of EPS/tardive dyskinesia. Schizophrenic patients on CPZ (chlorpromazine) develops auditory hallucination should be treated with Clozapine MECHANISM OF ACTION: Selective monoaminergic antagonist. High affinity for serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 & 2 adrenergic, and H1 histaminergic receptors. More affinity towards D1 receptors than D2
Clozapine Q. 1 Drug of choice for schizophrenic patient with poor oral absorption is?  A Haloperidol  B Fluphenazine  C Clozapine  D Olanzapine Q. 1 Drug of choice for schizophrenic patient with poor oral absorption is?  A Haloperidol  B Fluphenazine  C Clozapine  D Olanzapine Ans. C Explanation: Clozapine REF: Kaplan and sadock’s synopsis in psychiatry 10th ed
