Etiopathogenesis

Etiopathogenesis of schizophrenia-Neuropathological factors

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Etiopathogenesis of schizophrenia-Neuropathological factors The etiopathogenesis of schizophrenia consists of following factors: Genetic Biochemical Neuropathological Neuropathological Factors: Cerebral Ventricle s – ↓ Cerebral Grey Matter and ↑ Lateral and 3rd Ventricle Limbic System – ↓ Hippocampus, ↓ Amygdala, ↓ Para hippocampal Gyrus Abnormalities of Prefrontal Cortex, basal ganglia and cerebellum Neuronal Loss in MEDIAL DORSAL […]

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Etiopathogenesis of schizophrenia-Genetic factors

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 Etiopathogenesis of schizophrenia-Genetic factors The etiopathogenesis of schizophrenia consists of following factors: Genetic Biochemical Neuropathological Genetic Factors: Nine Linkage sites identified – 1q, 5q, 6p, 8p, 10p, 13q, 15q, 22q α- 7 nicotinic receptor DISC 1 [Disrupted in Schizophrenia] COMT [Catechol-o-methyl transferase] NRG 1 [Neuregulin 1] GRM 3 [Glutamate receptor metabotropic] RGS 4 [Regulator

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Etiopathogenesis of schizophrenia-Biochemical factors

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Etiopathogenesis of schizophrenia-Biochemical factors The etiopathogenesis of schizophrenia consists of following factors: Genetic Biochemical Neuropathological Biochemical factors: Dopamine Hypothesis – Excess of dopaminergic activity Serotonin – Currently along with dopamine excess of serotonin is also considered Other Neurotransmitter – GABA, NE, Ach, Nicotine, Glutamate

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