TUMOR PROTEIN 53 (TP53) Q. 1 About p53 all are true except  A Encodes 53k Da protein  B Located on Chr. 17  C Arrests cell cycle at GI phase  D Wild type p53 is associated with childhood tumors. Q. 1 About p53 all are true except  A Encodes 53k Da protein  B Located on Chr. […]
TUMOR PROTEIN 53 (TP53) TUMOR PROTEIN 53/TP53 INTRODUCTION: One among “Tumor suppressor gene”. A Phosphoprotein, barely detectable in nucleus of normal cells. Also referred to as “Molecular policeman”/“Guardian angel of genome” Due to its protective role in cell cycle. Hallmarks of cancer. In non-stressed, healthy cells has short half-life~20 mins Due to its association with MDM2. MDM2 – Negative
