Vitamin C- Scurvy

Vitamin C Deficiency–

1. Scurvy-

• Petechaie, ecchymosis, bleeding gums, joint effusion, fatigue.
• Perifollicular haemorrhages
• Hyperkeratotic papules
• Anemia
• Late stages characterized by edema, oliguria, neuropathy, death.
• Bowing of legs is seen in Scurvy.
• Radiological signs of scurvy are Winberger sign, Trimmerfeld zone, Frenkel’s line , Pelican spur, Bony thickening, Metaphyseal porosis, Metapyseal infarction, Metaphyseal calcification, Epiphyseal separation, Cortical spur
• ‘Pelkan spur’ is a radiological feature of Scurvy.
• Exhaustive treatise on scurvy was published by James Lind.

• Vitamin C cannot be produced in humans due to lack of: L-gulonolactone oxidase

  
  

2. Barlows Syndrome (Infantile Scurvy)- 6-12 months

Vitamin C Toxicity-

• Gastric irritation, diarrhea, oxalate stones.

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