XENON
Introduction:
- Xenon (Xe) – Nobel or inert gases.
- Colorless, odorless, non-flammable & non-explosive.
- Heavy gas (4.5 times heavier than air).
MOA:
- Anesthetic action by non-competitive blockade of NMDA receptors.
- Weak anesthetic.
Properties:
- Very low blood gas partition coefficient i.e., 0.14 (even less than desflurane).
- Hence, induction (onset) & recovery are very fast.
- MAC = 71%.
Potency:
- More potent than N2O.
- Less potent than other inhalational anesthetics.
Actions:
On CVS:
- Provides good hemodynamic stability.
- Minimal cardiovascular side effects – Useful in mitral stenosis.
-
- Minor changes in BP.
- Slight reduction in HR
-
On circulation:
- High regional blood flow in brain, liver, kidney & intestine.
On CNS:
- Increases cerebral blood flow & ICT – Used with caution in raised ICT risk patients.
Advantages & uses:
- Very close to ideal anesthetics.
- Yet, uncommonly used due to high cost, unavailability, low potency, unavailability of commercially available anesthesia equipment & unmeasurable concentration with conventional anesthetic gas analyzers.
- Radiodense property.
- Xe-133 used to enhance CT images of brain & measure cerebral blood flow.
- Greatly reduces tissue hypoxia.
- Acts as an alternative for transplant surgery.
- Does not trigger malignant hyperthermia.
Adverse effects:
- Exerts concentration effect.
- Second gas effect.
- Diffusion hypoxia.
Exam Important
- In Patient with mitral stenosis, & liver compromise Xenon inhalational agent is preferred.
- Rapid induction and recovery are seen in Xenon.
- Xenon has Low potency.
- Xenon is Non-explosive.
- Minimal cardiovascular side effects are seen with Xenon.
- Xenon inhibits Ca. pump and low blood gas solubility.
- Xenon acts through NMDA receptors.
Don’t Forget to Solve all the previous Year Question asked on XENON
Click Here to Start Quiz
Click Here to Start Quiz
