5 hydroxy indole acetic acid in urine is seen in
C. Hirschsprung’s disease
D. Wilm’s tumor
Answer is ‘a’ i.e. Carcinoid syndrome
Carcinoid syndrome is due to excessive production of serotonin, a product of tryptophan metabolism.
It is characterized by cutaneous flushing, abdominal cramps, and diarrhea.
It is then metabolized and excreted in urine as 5-HIAA. Thus urine levels of 5-HIAA are used for the diagnosis of carcinoid syndrome.
→ Gastrointestinal Neuroendocrine Tumors [Argentaffin Cells → Serotonin]
→ Intermittent Diarrhea and Flushing [Most Common]
→ Sweating , Fluctuating Hypertension , Pellagra Like Symptoms
→ ↑ S Serotonin with Increase in 5HIAA
→ Neuroendocrine Markers Positive
1. Chromogranin A
2. Neuron Specific Enolase