Image Based Question – 65213

Segment ‘4’ of this structure shown in the photograph has which of the following?

A. Na+ Cl- cotransporter

B. Na+ 2Cl- K+ cotransporter

C. Na+K channel

D. Na+ Amino acid cotransporter

Show Answer

Correct Answer » B Explanation

Ans is B

This segment is loop of Henle of nephron & it has Na+-2Cl- cotransporter

Distal tubule:

Has 2 functionally distinct segments:

• Early segment of distal tubule

• Late segment of distal tubule

1. Early segment of distal tubule:

• Also referred as “Proximal” part of distal tubule.

• Functionally identical to thick ascending limb of loop of Henle

Function:

• Overall impact is to urine dilution by removing solutes.

• Approximately 7% of filtered Na+ is reabsorbed by sodium chloride cotransporter (Na’ Cl-cotransporter.

• From cell Na+ transported out in the interstitial fluid by Na. K* ATPase located in the basolateral membrane.

2. Late segment of distal tubule:

• Has characteristics similar to cortical part of collecting duct (cortical collecting tubule)