Question
The progressive midbrain involvement leads to the typical “pareidolic sign” as represented by an arrow in the picture below are seen in cases of ?
A. Wilson’s disease.
B. Crohn’s disease.
C. Sarcoidosis.
D. Glioblastoma.
Show Answer
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Correct Answer » A
Explanation
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The progressive midbrain involvement leads to the typical pareidolic sign known as (face of a giant panda sign as represented by a red arrow in the picture above) in Wilson’s disease.
This sign occurs when the MR signal is preserved at the red nucleus, lateral portion of the substantia nigra pars reticulata; is increased at the mesencephalic tegmentum; and decreased at the superior colliculi.Treatment is based on anti-copper agents such as D-penicilamine and Trientine, aimed at quelling copper toxicity. Zinc may be of help as it interferes with copper absorption at the gastro-intestinal tract and therefore reduces its uptake.
