Question
Risk factor for Car cinoma of Organ shown in image marked with(A) is/are:
A. Typhoid carrier stage
B. Adenomatous Polyps
C. Choledochal cysts
D. All of the above
Show Answer
|
Correct Answer » D Explanation |
 |
Ans:D. All of the above.
Gall Bladder Carcinoma
Risk factors:
- Gender—approx. twice more common in women than men, usually in seventh and eighth decades.
- Obesity increases the risk for gallbladder cancer.
- Chronic cholecystitis and cholelithiasis.
- Primary sclerosing cholangitis, ulcerative colitis, liver flukes, chronic Salmonella typhi and paratyphi infections, and Helicobacter infection.
- Ingestion of certain medications (eg, oral contraceptives, INH, methyldopa) can increase the risk of gallbladder cancer , certain chemical exposures (eg, pesticides, rubber, vinyl chloride) .
- Exposures through water pollution (organopesticides, eg, dichlorodiphenyltrichloroethane and benzene hexachloride); heavy metals (eg, cadmium, chromium, lead); and radiation exposure (eg, radon in miners) .
- Various single nucleotide polymorphisms (SNPs) have been shown to be associated with gallbladder cancer.
- An increased incidence of gallbladder cancer also occurs in hereditary syndromes including the following :
- Gardner syndrome
- Neurofibromatosis type I
- Hereditary nonpolyposis colon cancer.
- Abnormal anatomy such as congenital defects with anomalous pancreaticobiliary duct junctions and choledochal cysts
