Image Based Question-65405

This condition of cells  is due to which type of mutation?

A. Frame-shift mutation.

B. Base substitution mutation.

C. Trinucleotide repeat.

D. Splice site mutation.

Correct Answer » B Explanation

These cells are Sickel cell

Ans. is ‘b’ i.e., Base substitution mutation

• Sickle cell anemia is a hereditary hemoglobinopathy, i.e., the type of disease characterized by production of defective hemoglobin.
• Sickle cell anemia results from mutation in β-globin gene.
• It is caused by a point mutation (Base substitution mutation) at the sixth position of the β-globin chain leading to subsitution of a valine residue for a glutamic acid residue resulting in sickle hemoglobin (HbS).
• Sickle cell anemia is an autosomal recessive disorder.