Question
Typical appearance of cell shown in Smear Photograph is found in
A. Microcytic hypochromic anemia.
B. Megaloblastic anemia.
C. Sideroblastic anemia.
D. Hemolytic anemia.
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Correct Answer » B Explanation |
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Ans: B. Megaloblastic anemia
Cell shown in the image is Hypersegmented neutrophil
- Normal neutrophils only contain three or four nuclear lobes (the “segments”), Hypersegmented neutrophils contain six or more lobes.
- Hypersegmented neutrophils have classically been thought to be pathognomonic of the class of anemias called megaloblastic anemias
- These anemia are caused by failure of bone marrow blood-forming cells to make DNA, often caused by vitamin B12 or folate deficiencies, or DNA-replication poisons.