Image Based Question-65409

 Typical appearance of cell shown in Smear Photograph is found in

A. Microcytic hypochromic anemia.

B. Megaloblastic anemia.

C. Sideroblastic anemia.

D. Hemolytic anemia.

Correct Answer » B Explanation

Ans: B. Megaloblastic anemia

Cell shown in the image is Hypersegmented neutrophil

• Normal neutrophils only contain three or four nuclear lobes (the “segments”), Hypersegmented neutrophils contain six or more lobes.
• Hypersegmented neutrophils have classically been thought to be pathognomonic of the class of anemias called megaloblastic anemias
• These anemia are caused by failure of bone marrow blood-forming cells to make DNA, often caused by vitamin B12 or folate deficiencies, or DNA-replication poisons.