Image Based Question-65451

The blood smear of a patient shows the following as represented in the picture below. Identify the structure marked as “A and B”?

A. A-Cabot ring

B-Howell-Jolly body.

B. A-Howell-Jolly body

B-Cabot ring.

C. A-Cabot ring

B-Spurr cells.

D. A-Spurr cells

B-Burr cells.

Correct Answer » A Explanation

A-Cabot ring

B-Howell-Jolly body.

Howell–Jolly bodies 

• They are histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes.
• During maturation in the bone marrow late erythroblasts normally expel their nuclei, but in some cases a small portion of DNA remains.
• Its presence usually signifies a damaged or absent spleen because a healthy spleen would normally filter this type of red blood cell.
• Howell–Jolly bodies are also seen in: amyloidosis, severe hemolytic anemia, megaloblastic anemia, hereditary spherocytosis, heterotaxy with asplenia and myelodysplastic syndrome (MDS).
• Also can be seen in premature infants.

Cabot ring

• They are thin, red-violet staining, threadlike strands in the shape of a loop or figure-8 that are found on rare occasions in red blood cells (erythrocytes).
• They are believed to be microtubules that are remnants from a mitotic spindle, and their presence indicates an abnormality in the production of red blood cells.
• Cabot rings have been observed in megaloblastic anemia, lead poisoning, severe anemia, leukemia, myelodysplastic syndromes, and other cases of dyserythropoiesis.