A. Dose of Drug.
B. Frequency of Drug.
C. Therapeutic index of Drug.
D. All of the above.
And:D. All of the above: Dose of Drug, Frequency of Drug, Therapeutic index of drug
Image shows Drug Response Curve
Drug Response Curve
- Refers to the relationship between some effect—e.g. lowering of blood pressure—and the amount of a drug.
- A hypothetical dose-response curve has features that vary: Dose-response, which involves the principles of pharmacokinetics and pharmacodynamics, determines the required dose and frequency as well as the therapeutic index for a drug in a population.
- Potency (location of curve along the dose axis)
- Maximal efficacy or ceiling effect (greatest attainable response)
- Slope (change in response per unit dose).
- The therapeutic index (ratio of the minimum toxic concentration to the median effective concentration) helps determine the efficacy and safety of a drug.