Question
The drug shown in the picture below is metabolized by?
A. Acetylation.
B. Oxidation.
C. Reduction.
D. Hydrolysis.
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Correct Answer » A Explanation |
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Ans:A. Acetylation.
The drug shown in the picture above is Isoniazid which is metabolized by Acetylation.
Isoniazid is extensively metabolized in liver .Most important pathway being N – acetylation
The acetylated metabolite is excreted in urine.
Drugs metabolized by acetylation
- Sulfonamides (including dapson)
- Procainamide
- PAS
- INH
- Hydralazine