Image Based Question-65660

A 45 years old female patient presented painless supraclavicular lymphadenopathy. Biopsy revealed these cells, appearance with floating lymphocytes in empty space, which was CD 15, CD 30 positive. What is the most probable diagnosis.

A. Lymphocytic predominant Hodgkin’s lymphoma.

B. Nodular sclerosis Hodgkin lymphoma.

C. Mixed cellularity Hodgkin lymphoma.

D. Lymphocytic depleted lymphoma.

Correct Answer » B Explanation

These cells are Owl eye like inclusion bodies

Biopsy revealed binucleated acidophilic owl eye appearance with floating lymphocytes in empty space, which was CD 15, CD 30 positive. The most probable diagnosis is Hodgkin’s lymphoma. Nodular sclerosis, mixed cellularity and lymphocyte-depleted variants are positive for CD 15 and CD30. But Nodular sclerosis variant is most common type and more common in females