Question
Below shown is an enveloped,double stranded DNA virus which primarily infects B cells of the patient .Entry of this virus in the B cells is through interation with which receptors?
A. CD 3
B. Cd 4
C. CD 8
D. CD 21
Show Answer
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Correct Answer » D Explanation |
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Ans. is ‘d’ i.e., CD 21
This virus shown in the image is Epstein-Barr virus
Epstein – Barr Virus (EBV)
Epstein – Barr Virus (EBV)
- Belongs to Herpes viruses family(Enveloped,Double stranded DNA Virus with Icosahedral capsid)
- Infection with EBV occurs by the oral transfer of saliva and genital secretions.
- EBV infects B cells of the immune system and epithelial cells.EBV latency persists in the individual’s B cells for the rest of the individual’s life.
- EBV has been implicated in several diseases, including infectious mononucleosis,Burkitt’s lymphoma,Hodgkin’s lymphoma,stomach cancer,nasopharyngeal carcinoma,Hairy cell Leukoplakia,multiple sclerosis,and lymphomatoid granulomatosis.
To enter B cells, viral glycoprotein gp350 binds to cellular receptor CD21.
- Then, viral glycoprotein gp42 interacts with cellular MHC class II molecules. This triggers fusion of the viral envelope with the cell membrane, allowing EBV to enter the B cell.
- Human CD35 is an additional attachment factor for gp350/220, and can provide a route for entry of EBV into CD21-negative cells, including immature B-cells.