Image Based Question-66251

Identify the hematological disorder shown in photograph ?

A. Iron deficiency anemia.

B. Megaloblastic anemia.

C. Thalassemia.

D. Lead poisoning.

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Correct Answer » B Explanation

Findings of megaloblastic anemia

Peripheral blood

• Macrocytosis megaloblastic RBC → Due to nuclear/cytoplasmic asynchrony.

• Macrocytes lack central pallor of normal RBC.

• Anisopoikilocytosis → Marked variation in shape and size.

• Majority of RBCs appear as macroovalcytes.

• Few tear drop cells.

• Low reticulocyte count

• Some nucleated RBCs may appear (normally, during maturation of RBC, nucleus disappears).

• Hyper-segmented neutrophils → First manifestation of megaloblastic anemia.
  Large megakaryocytes with multilobate nuclei.

• Evidence of erythropoiesis : – Basophilic stippling, Cabott Ring, Howell-jolly bodies.