Question
Lesion in the area in the brain marked by purple colour can lead to?
A. Chorea.
B. Addiction.
C. Parkinson’s disease.
D. All of the above.
Show Answer
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Correct Answer » D Explanation |
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Ans:D. All of the above.
Striatum is shown in the image(marked by purple colour)
Striatum
- The striatum (also the neostriatum and the striate nucleus) is one of the nuclei in the subcortical basal ganglia of the forebrain.
- The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia nuclei.
- Functionally, the striatum coordinates multiple aspects of cognition, including motor- and action- planning, decision-making, motivation, reinforcement, and reward perception.
Clinical significance
- Parkinson’s disease
- Parkinson’s disease results in loss of dopaminergic innervation to the dorsal striatum (and other basal ganglia) and a cascade of consequences.
- Atrophy of the striatum is also involved in Huntington’s disease, choreas, choreoathetosis, and dyskinesias.
- Addiction
- Addiction, a disorder of the brain’s reward system.
- Bipolar disorder
- Dysfunction
- Dysfunction in the ventral striatum can lead to a variety of disorders, most notably, depression and obsessive-compulsive disorder.
