Question
Identify the pathological process as shown in this image of histopathological examination of pancreas.
A. Liquefactive Necrosis
B. Caseous Necrosis
C. Fat Necrosis
D. Coagulative Necrosis
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Correct Answer » C Explanation |
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Ans:C.)Fat Necrosis.
Image shows:Fat necrosis in acute pancreatitis. There is cloudy appearance of adipocytes, coarse basophilic granular debris while the periphery shows a few mixed inflammatory cells.
FAT NECROSIS.
- Fat necrosis is a special form of cell death occurring following acute pancreatic necrosis, and traumatic fat necrosis commonly in breasts.
- In the case of pancreas, there is liberation of pancreatic lipases from injured or inflamed tissue that results in necrosis of the pancreas as well as of the fat depots throughout the peritoneal cavity, and sometimes, even affecting the extraabdominal adipose tissue.
- Fat necrosis hydrolyses neutral fat present in adipose cells into glycerol and free fatty acids.
- The damaged adipose cells assume cloudy appearance.
- The leaked out free fatty acids complex with calcium to form calcium soaps (saponification).
- Grossly, fat necrosis appears as yellowish-white and firm deposits.
- Formation of calcium soaps imparts the necrosed foci firmer and chalky white appearance.
- Microscopically, the necrosed fat cells have cloudy appearance and are surrounded by an inflammatory reaction.
- Formation of calcium soaps is identified in the tissue sections as amorphous, granular and basophilic material.
