Image Based Question-69907

All the following statements are true about the cell modification marked by “E” in the image except:

A. Divided into 2 types: epithelial and mesenchymal.

B. Disordered cellular development

C. May regress on removal of inciting stimulus

D. May progress to carcinoma in situ

Correct Answer » A Explanation

Ans:A. Divided into 2 types: epithelial and mesenchymal.

Dysplasia is shown in the image.

DYSPLASIA

• Dysplasia means ‘disordered cellular development’, also referred to as atypical hyperplasia.
• Dysplasia occurs most often in epithelial cells.
• Epithelial dysplasia is characterised by cellular proliferation and cytologic changes.
• • Increased number of layers of epithelial cells
  • Disorderly arrangement of cells from basal layer to the surface layer
  • Loss of basal polarity i.e. nuclei lying away from basement membrane
  • Cellular and nuclear pleomorphism
  • Increased nucleocytoplasmic ratio
  • Nuclear hyperchromatism
  • Increased mitotic activity.
• The two most common examples of dysplastic changes are the uterine cervix  and respiratory tract.
• Dysplastic changes often occur due to chronic irritation or prolonged inflammation.
  • On removal of the inciting stimulus, the changes may disappear. In a proportion of cases, however, dysplasia progresses into carcinoma in situ (cancer confined to layers superficial to basement membrane) or invasive cancer.