Image Based Question – 70376

Correct Answer » C Explanation

Ans:C. Condyloma.

Image shows:A, Numerous condylomas of the vulva. B, Histopathologic features of condyloma acuminatum include acanthosis, hyperkeratosis, and cytoplasmic vacuolation (koilocytosis, center).

Condylomas

• Condyloma is the name given to any warty lesion of the vulva.

• Condylomata lata, not commonly seen today, are flat, moist, minimally elevated lesions that occur in secondary syphilis.

• The more common condylomata acuminata may be papillary and distinctly elevated or somewhat flat and rugose.

• They can occur anywhere on the anogenital surface, sometimes as single but more often as multiple lesions.

• When located on the vulva, they range from a few millimeters to many centimeters in diameter and are red-pink to pink-brown .

• On histologic examination, the characteristic cellular feature is koilocytosis, a cytopathic change characterized by perinuclear cytoplasmic vacuolization and wrinkled nuclear contours that is a hallmark of HPV infection. Indeed, condylomata acuminata are strongly associated with HPV subtypes 6 and 11.

• HPV can be transmitted venereally, and identical lesions occur in men on the penis and around the anus.

• HPV 6 and 11 infections carry a low risk of malignant transformation, and hence, vulvar condylomas do not commonly progress to cancer.