A. Squamous Cell Carcinoma
D. Lichen sclerosus
Image shows:A, Numerous condylomas of the vulva. B, Histopathologic features of condyloma acuminatum include acanthosis, hyperkeratosis, and cytoplasmic vacuolation (koilocytosis, center).
- Condyloma is the name given to any warty lesion of the vulva.
- Condylomata lata, not commonly seen today, are flat, moist, minimally elevated lesions that occur in secondary syphilis.
- The more common condylomata acuminata may be papillary and distinctly elevated or somewhat flat and rugose.
- They can occur anywhere on the anogenital surface, sometimes as single but more often as multiple lesions.
- When located on the vulva, they range from a few millimeters to many centimeters in diameter and are red-pink to pink-brown .
- On histologic examination, the characteristic cellular feature is koilocytosis, a cytopathic change characterized by perinuclear cytoplasmic vacuolization and wrinkled nuclear contours that is a hallmark of HPV infection. Indeed, condylomata acuminata are strongly associated with HPV subtypes 6 and 11.
- HPV can be transmitted venereally, and identical lesions occur in men on the penis and around the anus.
- HPV 6 and 11 infections carry a low risk of malignant transformation, and hence, vulvar condylomas do not commonly progress to cancer.