Question
A 5 year old girl presented with recurrent skin lesions over the body as shown in the image following trivial trauma.What can be the most possible diagnosis?
A. Dermatitis Herpetiformis
B. Epidermolysis Bullosa
C. Bullous Pemphigoid
D. Pemphigous Vulgaris
Show Answer
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Correct Answer » B
Explanation
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Ans:B. Epidermolysis Bullosa.
Epidermolysis Bullosa
Epidermolysis bullosa (EB) is a group of inherited bullous disorders characterized by blister formation in response to trivial mechanical trauma.
Pathophysiology:
- Epidermolysis bullosa is a family of bullous disorders caused by an absence of basement membrane components due to underlying gene mutations.
- Epidermolysis bullosa is classified into three major categories:
- epidermolysis bullosa simplex (intraepidermal skin separation),
- junctional epidermolysis bullosa (skin separation in lamina lucida or central BMZ), and
- dystrophic epidermolysis bullosa (sublamina densa BMZ separation).
Junctional epidermolysis bullosa: minor trauma
has caused large blisters and erosions which will heal
slowly or not at all.
Autosomal recessive dystrophic epidermolysis
bullosa: note large blood-filled blister. Scarring has led to
fixed deformity of the fingers and loss of nails.
