A. Long term UV light exposure is implicated as the cause.
B. May progress to Basal Cell Carcinoma.
C. Most common lesion with malignant potential to arise on the skin.
D. Characterised by Dysplasia.
Ans:B. May progress to Basal Cell Carcinoma
The patient in question is suffering from Actinic Keratosis.
- lt is a UV light-induced lesion of the skin that may progress to invasive squamous cell carcinoma.
- Most common lesion with malignant potential to arise on the skin.
- Actinic keratoses arise on fair-skinned people in areas of long-term sun exposure, such as the face, ears, bald scalp, forearms, and backs of the hands.
- They may occur on any area that is repeatedly exposed to the sun, such as the back, the chest, and the legs.
- Long term UV light exposure is implicated as the cause from both epidemiologic observations and molecular analysis of tumor cells.–
- Clinically, actinic keratoses range from barely perceptible rough spots of skin to elevated, hyperkeratotic plaques several centimeters in diameter.
- Most often, they appear as multiple discrete, flat or elevated, keratotic lesions.
- Lesions typically have an erythematous base covered by scale (hyperkeratosis).
- They are usually 3-10 mm in diameter and gradually enlarge into broader, more elevated lesions.–
- Over time, actinic keratoses may develop into invasive squamous cells.
- A skin biopsy is indicated to confirm the diagnosis and to rule out invasive squamous cell carcinoma:
- Actinic keratosis is characterized by dysplasia and architectural disorder of the epidermis, as follows :
- Abnormal keratinocytes of the basal layer that are variable in size and shape
- Altered cellular polarity
- Nuclear atypia
- Hyperkeratosis and parakeratosis of the epidermis
- Irregular acanthosis may be present