Question
Below shown is a pedigree chart.From the following given options,which of the disease would follow the inheritance pattern shown in the image?
A. Achondroplasia
B. Albinism
C. Hemophilia A
D. Leber hereditary optic neuropathy
Show Answer
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Correct Answer » A
Explanation
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Ans:A. Achondroplasia
Autosomal inheritance pattern is shown in the image.
FEATURES OF AUTOSOMAL DOMINANT INHERITANCE
- Affected children usually have affected parents, which tends to result in the absence of skipped generations.
- There is a 50% chance of a child inheriting the gene from an affected parent.
- There is no carrier state.
- Males and females are equally likely to transmit the phenotype and to be affected.
- Many autosomal dominant diseases arise via new mutations.
ORGAN-BASED AUTOSOMAL DOMINANT DISEASES
- Autosomal dominant polycystic kidney disease
- Charcot-Marie-Tooth disease (most forms)
- Crigler-Najjar syndrome type II
- Ehlers-Danlos syndrome (certain forms)
- Familial hypertrophic cardiomyopathy
- Hereditary hemorrhagic telangiectasia
- Multiple polyposis syndromes
- von Hippel-Lindau syndrome
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