C. Human papilloma Virus
D. Herpes Simplex Virus
Ans:C. Human papilloma Virus.
Koilocytes are seen in the Pap Smear.
A koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus.
Koilocytes may have the following cellular changes:
- Nuclear enlargement (two to three times normal size)
- Irregularity of the nuclear membrane contour
- A darker than normal staining pattern in the nucleus, known as Hyperchromasia
- A clear area around the nucleus, known as a perinuclear halo.
Collectively, these types of changes are called a cytopathic effect