Image Based Question – 73869

A 17-year-old patient develops intussusception for which he was operated and a segment of intestine showing multiple polyps was resected. Microscopy showed the following pathology. What is the likely diagnosis?

A. Tubulovillous polyps

B. Hamartomatous polyps

C. Inflammatory polyps

D. Adenocarcinoma

Correct Answer » B Explanation

Ans: B. Hamartomatous polyps

(Ref Sabiston 20/e p1372, 19/e p1342; Schwartz 10/e p1206 9/e p1042-104:3; Bailey 27/e p12.50. 26/e p1161-1164)

• The given histology shows a large and pedunculated polyp with a firm lobulated contour.
• An arborizing network of connective tissue is seen with well-developed smooth muscle extending into the polyp and surrounding normal abundant glands lined by normal intestinal epithelium rich in goblet cells.
• This is typical of Peutz-Jegher’s polyps, which are a type of hamartomatous polyp.