Question
A 35 years old female presented with an adnexal mass. CAl25 was slightly raised, CA199 was normal and LDH was elevated. Tumor was resected and the gross and microscopic image was as given below. What is the most likely diagram?
A. Papillary serous cystadenocarcinoma
B. Dysgerminoma
C. Teratoma
D. Choriocarcinoma
Show Answer
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Correct Answer » B
Explanation
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Ans: B. Dysgerminoma
(Ref Shaw ‘S 16/e p441-442, 15/e p378; Novak’s 15/e p1506-1508; Robbins 9/e p1031)
- Tumor described is suggestive of dysgerminoma.
Dysgerminomas:
- Unilateral tumors ((80% to 90%) ranging in size from barely visible nodules to masses fills entire abdomen.
- Solid yellow-white to gray-pink appearance on slicing.
- Soft & fleshy.
Histology:
- Composed of large vesicular cells with clear cytoplasm, well-defined cell boundaries & centrally placed regular nuclei.
- Tumor cells grow in sheets or cords separated by scant fibrous stroma infiltrated by mature lymphocytes & occasional granulomas.
