Image Based Question – 74386

A child comes with the history of pain in the right hip and difficulty in walking. X-ray hip was done as seen in the picture. Which of the following is the most likely diagnosis?

A. Osteopetrosis

B. Osteoporosis

C. Osteopoikilocytosis

D. Osteogenesis imperfecta

Correct Answer » A Explanation

Ans: A. Osteopetrosis

(Ref Apley 9/e p166)

• History highly suggestive of osteopetrosis.

Osteopetrosis (Marble Bones, Albers–Schonberg Disease):

• Osteopetrosis is one of several conditions which are characterized by sclerosis and thickening of the bones which appear with increased radiographic density.
• This is the result of an imbalance between bone formation and bone resorption.
• Failed bone resorption due to a defect in osteoclast production and/or function.