Question
A patient presented with a 4 months’ history of cough with diarrheal episodes. Bronchoscopy revealed an intrabronchial polyp. Biopsy from the polyp showed atypical cells with microscopic necrosis and 5 mitotic figures per 10 high-power fields as shown below. Chromogranin staining was positive. What is the diagnosis and grade of the lesion?
A. Atypical carcinoid grade 2
B. Carcinoid grade 1
C. Small cell carcinoma grade IV
D. Large cell ncuroendocrine carcinoma Grade IV
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Correct Answer » A Explanation |
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Ans: A. Atypical carcinoid grade 2
(Ref: Robbins 9/e p719-720).
- History of diarrhea with cough and associated findings are suggestive of carcinoid syndrome.
- Positivity for chrontogranin confirms the neuroendocrine origin of the tumor.
- Typical carcinoids have
- These are traditionally classified
- as grade 2 carcinoids.
- Hence the patient is having a grade 2 atypical carcinoid.